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Rifamycin B. oxidase from Monocillium spp., a new type of diphenol oxidase
Author(s) -
Han Moon H.,
Baik-Lin Seong,
Son Hyeung-Jin,
Tae-Ick Mheen
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80337-8
Subject(s) - rifamycin , polyphenol oxidase , chemistry , enzyme , oxidase test , biochemistry , laccase , hydrolysis , stereochemistry , antibiotics , peroxidase
It was found that enzyme from a microbial strain, Monocillium spp. ATCC 20621, catalyzed the oxidative reaction of rifamycin B to form rifamycin O. The identification of the reaction products suggested that the reaction proceeded by the oxidative cyclization of rifamycin B to give rifamycin O, which spontaneously hydrolyzed to rifamycin S in neutral aqueous milieu. The characteristic of the enzyme was different as compared with that of other polyphenol oxidases such as laccase. It is proposed that this new type of enzyme be classified into a subgroup EC 1.10.3.6 with a trival name rifamycin B oxidase.