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Antioxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low‐level chemiluminescence and alkane production
Author(s) -
Bartoli Gianna M.,
Müller Armin,
Cadenas Enrique,
Sies Helmut
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80319-6
Subject(s) - chemiluminescence , lipid peroxidation , chemistry , antioxidant , glutathione , alkane , thiol , penicillamine , biochemistry , induction period , chromatography , organic chemistry , enzyme , catalysis
Different thiol‐containing compounds, such as diethyldithiocarbamate (DDC), glutathione, penicillamine, and dithioerythritol have been chosen to study their effect on ascorbate/Fe‐ADP‐induced lipid peroxidation, detected by low‐level chemiluminescence and alkane production. In the concentration range used, these thiols exerted a temporary protection against lipid peroxidation by lengthening the induction period; after overcoming this induction period, no substantial inhibition of either chemiluminescence or alkane production was observed. DDC was effective in protecting against lipid peroxidation in the nanomolar range, whereas the group of other thiol‐containing molecules operated in the millimolar range.