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Will the seven‐helix bundle be a common structure for integral membrane proteins?
Author(s) -
Mohana Rao J.K.,
Hargrave Paul A.,
Argos Patrick
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80270-1
Subject(s) - bacteriorhodopsin , thylakoid , integral membrane protein , rhodopsin , transmembrane protein , membrane protein , transmembrane domain , chloroplast , biophysics , membrane , halobacterium , chemistry , peripheral membrane protein , biochemistry , helix (gastropod) , biology , retinal , ecology , receptor , snail , gene
A prediction algorithm, designed to detect lipid‐embedded helical regions in membrane proteins, was applied to the amino acid sequence of a chloroplast thylakoid membrane protein important in photosynthesis. It is suggested that the thylakoid membrane protein consists of 7 transmembrane helices connected by exposed turn segments, similar to current models for bacteriorhodopsin and bovine rhodopsin. This basic structural feature, the 7‐helical bundle, may prove to be shared by many integral membrane proteins.