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Isolation and characterization of the mouse corticotropin‐β‐lipotropin precursor gene and a related pseudogene
Author(s) -
Notake Mitsue,
Tobimatsu Takamasa,
Watanabe Yumiko,
Takahashi Hideo,
Mishina Masayoshi,
Numa Shosaku
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80250-6
Subject(s) - pseudogene , gene , biology , genetics , homologous chromosome , genomic dna , peptide sequence , microbiology and biotechnology , genome
Two mouse genomic DNA sequences homologous with human corticotropin‐β‐lipotropin precursor gene sequences have been cloned. One of them represents the functional corticotropin‐β‐lipotropin precursor gene, which exhibits a structural organization similar to those of its bovine and human counterparts. The other represents a pseudogene that corresponds to the functional mouse gene sequence encoding the carboxy‐terminal 143 amino acid residues (including corticotropin and β‐lipotropin) and the 3′‐untranslated region.