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Complete amino acid sequence of the nucleic acid‐binding protein of bovine leukemia virus
Author(s) -
Copeland Terry D.,
Morgan M.Alice,
Oroszlan Stephen
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80243-9
Subject(s) - nucleic acid , bovine leukemia virus , biochemistry , peptide sequence , virology , sequence (biology) , chemistry , amino acid , leukemia , microbiology and biotechnology , virus , biology , genetics , gene
The complete amino acid sequence of the nucleic acid‐binding protein p12 of bovine leukemia virus (BLV) has been determined. Peptides were generated by enzymatic digestion and formic acid cleavage, purified by reversed‐phase liquid chromatography and subjected to automated Edman degradation. BLV p12 is a proline‐rich linear polypeptide composed of 69 amino acids with M r 7558. A comparison of the p12 structure to that of the avian and murine type C retroviral nucleic acid‐binding proteins shows significant homology only in the putative binding domain. This conserved region is duplicated in BLV p12 as in the avian homolog.