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Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon
Author(s) -
Chatzipanteli Katina,
Saggerson David
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80225-7
Subject(s) - lipolysis , medicine , endocrinology , glucagon , adenosine deaminase , adipocyte , streptozotocin , basal (medicine) , diabetes mellitus , insulin , chemistry , adenosine , adipose tissue
Adipocytes from streptozotocin‐diabetic rats are ∼50‐times more sensitive to the lipolytic action of glucagon. This change is only perceived in the presence of a small quantity of adenosine deaminase which itself has little effect on basal lipolysis. Insulin treatment restores glucagon sensitivity to normal.