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Rapid stopping of A23187 action by phosphatidylcholine
Author(s) -
Vidaver George A.,
Lee Jean W.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80221-x
Subject(s) - action (physics) , phosphatidylcholine , chemistry , biochemistry , physics , phospholipid , quantum mechanics , membrane
The action on pigeon erythrocytes of the Ca 2+ ionophore, A23187, can be nearly completely stopped within 30 s by treatment with a phosphatidylcholine dispersion at 39°C. A time‐limited 45 Ca 2+ uptake pulse can be produced by treating cells sequentially with A23187 and lipid, and the time‐course of expulsion of this 45 Ca 2+ uptake pulse can be easily determined.