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Restoration by insulin of the responsiveness of stimulated adipocytes to adenosine
Author(s) -
Lambert Bernard,
Jacquemin Claude
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80202-6
Subject(s) - lipolysis , medicine , endocrinology , adenosine , adenylate kinase , adipocyte , cyclase , phosphodiesterase , stimulation , insulin , chemistry , insulin sensitivity , ibmx , adipose tissue , biology , insulin resistance , enzyme , biochemistry , receptor , forskolin
The stimulation of adipocyte‐cyclase by isoproterenol decreases its sensitivity to adenosine, with, as a consequence, a decrease in its antilipolytic effect. The presence of insulin under conditions where its action on the phosphodiesterase activity is impaired, restores the responsiveness of adenylate‐cyclase and of lipolysis to adenosine.