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Red blood cell targeting to collagen‐coated surfaces
Author(s) -
Samokhin G.P.,
Smirnov M.D.,
Muzykantov V.R.,
Domogatsky S.P.,
Smirnov V.N.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80160-4
Subject(s) - antibody , red blood cell , bifunctional , chemistry , avidin , blood cell , cell , human blood , biophysics , microbiology and biotechnology , biochemistry , immunology , biology , biotin , physiology , catalysis
The interaction of human red blood cells carrying antihuman collagen antibody with collagen‐coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody‐carrying red blood cells efficiently and specifically bound to collagen‐coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.