Premium
Malignant hyperthermia in pigs: A search for abnormalities in Ca 2+ binding proteins
Author(s) -
Lorkin P.A.,
Lehmann H.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80123-9
Subject(s) - malignant hyperthermia , hyperthermia , chemistry , cancer research , biophysics , microbiology and biotechnology , medicine , biology , pathology
Malignant hyperthermia occurs in man and pigs as a hereditary disorder notably as a complication of halotane‐induced anaesthesia. It involves an abnormality in the metabolism of Ca 2+ . A search was made for abnormalities of calcium‐binding proteins. Troponin C from normal pig muscle was found to differ in 2 of 159 amino acids from rabbit Tn C and 3 from man. No differences between normal and abnormal pig muscle were found. Two‐dimensional electrophoresis of red cell calmodulin from normal and abnormal pigs also failed to demonstrate a difference.