Premium
The disulphide bonds of an Asian influenza virus neuraminidase
Author(s) -
Ward Colin W.,
Colman Peter M.,
Laver W.Graeme
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80113-6
Subject(s) - neuraminidase , virology , chemistry , virus , biology
The arrangement of the disulphide bonds in the pronase‐released neuraminidase heads of the Asian influenza virus A/Tokyo/3/67 have been examined by cyanogen bromide fragmentation, enzymic digestion and diagonal peptide mapping. There are 9 intrachain disulphide bridges and one interchain bridge which links pairs of monomers at the distal end of the stalk region of the neuraminidase tetramer. The disulphide bond arrangements of the remaining 3 half‐cystine residues in the membrane‐embedded stalk region of the neuraminidase were not examined.