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Compound 48/80‐induced permeability change in liposomal membrane
Author(s) -
Katsu Takashi,
Tasaka Kenji,
Fujita Yuzaburo
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80073-8
Subject(s) - liposome , chemistry , permeability (electromagnetism) , membrane , biophysics , biochemistry , biology
The action of compound 48/80 (a mixture of condensation products of p ‐methoxy‐ N ‐methylphenethylamine with formaldehyde) on liposomal membranes was studied by means of K + ‐loaded liposomes and a K + ion‐selective electrode. Prompt efflux of K + was detected when 48/80 was added to the negatively charged liposome suspension, while the monomer of 48/80, p ‐methoxy‐ N ‐methylphenethylamine, did not release K + from the same liposomes. The mechanism for the action of 48/80 is discussed in comparison with that of a polymyxin, well known as an antibiotic acting on bacterial membranes.