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Induction of 2′,5′ oligo(A) synthetase in tumor‐bearing mice with encephalomyocarditis (EMC) virus of poly(I)poly(C)
Author(s) -
Galaktidou G.,
Kortsaris A.,
Koliais S.I.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80041-6
Subject(s) - spleen , enzyme , virus , interferon , microbiology and biotechnology , inducer , biology , chemistry , virology , biochemistry , immunology , gene
Infection of 13 month‐old C 3 H mice with EMC virus or inoculation with the interferon inducer poly(I)poly(C) results in elevated levels of the enzyme 2′,5′ oligo(A) synthetase only in animals with spontaneous tumors (breast cancer or hepatomas). High enzymatic activities are detected in homogenates from liver, spleen, plasma and neoplastic cells of the animals with breast carcinomas and only in the neoplastic liver cells of the animals with hepatomas.