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The amino acid sequence of human spleen apoferritin
Author(s) -
Wustefeld Chantal,
Crichton Robert R.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81301-x
Subject(s) - peptide sequence , sequence (biology) , cleavage (geology) , amino acid , peptide , spleen , homologous chromosome , chemistry , biology , microbiology and biotechnology , biochemistry , gene , immunology , paleontology , fracture (geology)
The complete amino acid sequence of human spleen apoferritin has been determined. It consists of 174 amino acids, corresponding to M r 20017. The sequence is very similar to that of horse spleen apoferritin (14% difference between the two sequences). Some peptides were isolated and sequenced which could not be placed in the sequence but which are homologous with part of the principal sequence. Automatic sequence determination of a large peptide resulting from acid cleavage allows us to establish the presence of two homologous sequences (in the ratio ).