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Parathormone promotes glycogen formation from [ 14 C]glucose in cultured osteoblast‐like cells
Author(s) -
Schmid Ch.,
Steiner Th.,
Froesch E.R.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81236-2
Subject(s) - osteoblast , chemistry , glycogen , endocrinology , medicine , biochemistry , microbiology and biotechnology , biology , in vitro
Parathyroid hormone stimulates [U‐ 14 C]glucose incorporation into glycogen of cultured osteoblast‐like calvaria cells. This effect is detectable only several hours after the addition of PTH and it is mimicked by dibutyryl cyclic AMP. In contrast to insulin (in pharmacological concentrations), PTH enhances glycogen formation only in calvaria cells, but not in fibroblasts. Insulin‐like growth factor I in physiological concentrations promotes glycogen‐synthesis shortly after addition.