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Dansylsphingolipids for labelling and probing membranes
Author(s) -
Huang Richard T.C.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81215-5
Subject(s) - phosphorylcholine , membrane , labelling , fluorescence , chemistry , sphingolipid , sphingosine , biochemistry , galactose , fluorescent labelling , biophysics , biology , physics , receptor , quantum mechanics
Three fluorescent sphingolipids have been prepared, which contain dansyl sphingosine in the hydrophobic portion and various head groups (F‐Phosphorylcholine, galactose and lactose) in the hydrophilic end. These dansylphingolipids are readily incorporated into membranes and show affinity toward several membrane proteins. Results of fluorescence measurements indicate, that these lipids may be useful as probes for studying protein—lipid interactions.