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Does translational ambiguity increase during cell differentiation?
Author(s) -
Picard-Bennoun Marguerite
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81094-6
Subject(s) - podospora anserina , yeast , saccharomyces cerevisiae , ambiguity , biology , microbiology and biotechnology , translation (biology) , posttranslational modification , genetics , biochemistry , messenger rna , gene , computer science , enzyme , mutant , programming language
Several observations made in the fungus Podospora anserina suggest that translational ambiguity may increase, and possibly must increase, at specific stages of the life cycle. Such changes in the properties of the translational apparatus seem to occur as well in the yeast S. cerevisiae and in the alga C. reinhardii . A slight increase of the misreading level would allow readthrough or frameshifting necessary to synthesise regulatory proteins in low amount at key points of cellular differentiation.