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Monoclonal antibodies directed to human insulin‐like growth factor I (IGF I)
Author(s) -
Laubli Urs K.,
Baier Wolfgang,
Binz Hans,
Celio Marco R.,
Humbel René E.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81082-x
Subject(s) - radioimmunoassay , monoclonal antibody , antibody , insulin like growth factor , spleen , growth factor , somatomedin , insulin like growth factor 2 , biology , endocrinology , microbiology and biotechnology , medicine , immunology , receptor , biochemistry
Mouse hybridomas secreting antibodies to human insulin‐like growth factor I (IGF I) were produced by fusion of spleen cells of hyperimmunised mice with FO mouse‐myeloma cells. Eight clones producing antibodies against human IGF I have been isolated, two of which have been characterised. One was used in a radioimmunoassay, the other for immunopurification of IGF.