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A new candidate for the regulation of erythropoiesis
Author(s) -
Kurtz Armin,
Jelkmann Wolfgang,
Bauer Christian
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81081-8
Subject(s) - erythropoiesis , chemistry , medicine , anemia
The effect of pure human insulin‐like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU‐e) from fetal mouse liver and adult bone marrow was studied in a serum‐free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.