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The possible roles of the myosin heads
Author(s) -
Morel Jean E.,
Garrigos Manuel
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)81061-2
Subject(s) - myosin , myosin head , dimer , protein filament , actin , biophysics , molecule , head (geology) , chemistry , crystallography , myosin light chain kinase , biochemistry , biology , paleontology , organic chemistry
It is suggested that, in the conditions which exist in vivo , one head of a myosin molecule interacts with another head of the opposite molecule, inside the backbone of the thick filament. The other head lies outside and can interact with actin. This model is based on the fact that a dimer of the myosin heads exists and that there is a close correlation between the properties of the dimer and those of the thick filament diameter. In natural filaments, there are myosin molecules in excess and it is suggested that these molecules have their two heads outside the backbone.