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Glucose inhibits insulin release induced by Na + mobilization of intracellular calcium
Author(s) -
Hellman Bo,
Honkanen Tapio,
Gylfe Erik
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80826-0
Subject(s) - intracellular , insulin , calcium , cytoplasm , chemistry , calcium in biology , medicine , endocrinology , ouabain , biophysics , biochemistry , biology , sodium , organic chemistry
45 Ca 2+ incorporated in response to glucose was selectively mobilized from the β‐cell‐rich pancreatic islets of ob/ob‐mice after raising the intracellular Na + by removal of K + or addition of ouabain or veratridine. Also studies of insulin release indicated opposite effects of glucose and Na + on the intracellular sequestration of calcium. The fact that glucose inhibits insulin release induced by raised intracellular Na + indicates that this sugar can lower the cytoplasmic [Ca 2+ ]. The concept of a dual action of glucose on the cytoplasmic [Ca 2+ ]. The concept of a dual action of glucose on the cytoplasmic [Ca 2+ ] might well explain previous observations of an inhibitory component in the glucose action on the 45 Ca 2+ efflux.