Premium
The maximum capacity of glycolysis in brown adipose tissue and its relationship to control of the blood glucose concentration
Author(s) -
Cooney Gregory J.,
Newsholme Eric A.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80807-7
Subject(s) - glycolysis , phosphofructokinase , hexokinase , brown adipose tissue , adipose tissue , medicine , endocrinology , enzyme , chemistry , biology , biochemistry
The maximum activity of the key glycolytic enzymes, hexokinase and 6‐phosphofrustokinase, was measured in tissues of control and cold‐acclimated rats. The only significant change in activity was seen in brown adipose tissue where the activity of these enzymes was increased 2‐fold. This increase in glycolytic capacity along with the hypertrophy of BAT observed in cold acclimation suggests that this tissue could play an important role in glucose utilisation by the rat.