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The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts
Author(s) -
Gutteridge John M.C.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80788-6
Subject(s) - radical , chemistry , superoxide , phospholipid , hydroxyl radical , lipid peroxidation , photochemistry , biochemistry , antioxidant , membrane , enzyme
Iron(II) salts in aqueous solution, or iron(III) salts in the presence of an O − 2 generating system, can activate dioxygen to produce hydroxyl radicals. These are detected indirectly by their ability to degrade deoxyribose with the formation of thiobarbituric acid‐reactive (TBA) products. Iron salts also catalyse the peroxidation of phospholipids resulting in the formation of TBA‐reactive products. Hydroxyl radicals were responsible for the degradation of deoxyribose but not for the observed peroxidation of phospholipid. The function of O − 2 in both deoxyribose degradation and phospholipid peroxidation seems to be that of reducing iron(III) into iron(II).