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Differential effect of phenobarbital and β‐naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase
Author(s) -
Shephard Elizabeth A.,
Phillips Ian R.,
Pike Susan F.,
Ashworth Alan,
Rabin Brian R.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80771-0
Subject(s) - phenobarbital , cytochrome p450 , reductase , cytochrome p450 reductase , cytochrome , chemistry , messenger rna , biochemistry , enzyme , microbiology and biotechnology , biology , cytochrome c , coenzyme q – cytochrome c reductase , gene , pharmacology , mitochondrion
The induction in rat liver of a specific variant(s) of cytochrome P450 (PB‐P450) by phenobarbital and its repression by β‐naphthoflavone occur through corresponding changes in the levels of mRNA coding for the protein(s). The level of translatable mRNA coding for NADPH‐cytochrome P450 reductase in rat liver increases on treatment with phenobarbital but not β‐naphthoflavone.