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The generation of hydroxyl radicals following superoxide production by neutrophil NADPH oxidase
Author(s) -
Bannister J.V.,
Bellavite P.,
Davoli A.,
Thornalley P.J.,
Rossi F.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80755-2
Subject(s) - superoxide , radical , chemistry , nadph oxidase , hydroxyl radical , catalysis , photochemistry , fenton reaction , superoxide dismutase , oxidase test , superoxide radical , reactive oxygen species , biochemistry , enzyme
Stimulated neutrophils generate superoxide and hydroxyl radicals. A membrane‐bound NADPH oxidase, inactive in the resting state, is responsible for superoxide production. The production of hydroxyl radicals is through a secondary reaction. A Fenton‐catalysed Haber—Weiss reaction is proposed. Transferrin was used as the catalyst in this investigation.