Premium
Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileum
Author(s) -
Bataille D.,
Coudray A.M.,
Carlqvist M.,
Rosselin G.,
Mutt V.
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80708-4
Subject(s) - glucagon , ileum , chemistry , medicine , gastrointestinal hormone , endocrinology , cyclase , biochemistry , peptide hormone , hormone , biology , receptor
A 37 amino acid‐peptide has been isolated from porcine jejuno‐ileum on the basis of its glucagon‐like activity in liver (interaction with glucagon‐binding sites and activation of adenylate cyclase) using gel filtration, ion‐exchange and high‐performance liquid chromatography. Depending on the criteria chosen, this peptide is referred to as either ‘bioactive enteroglucagon’ (activity in liver), ‘oxyntomodulin’ (specific action in gastric oxyntic glands) or ‘glucagon‐37’ (chemical structure).