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Early presence of phospholamban in developing chick heart
Author(s) -
Will Horst,
Küttner Irmgard,
Vetter Roland,
Will-Shahab Liane,
Kemsies Christel
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80630-3
Subject(s) - phospholamban , chemistry , medicine , cardiology , biochemistry , endoplasmic reticulum
Phosphorylation of phospholamban and development of reticular Ca 2+ transport were studied in crude membrane preparations of embryonic, newborn and adult chick heart. Maximal phosphorylation of phospholamban by added catalytic subunit of cyclic AMP‐dependent protein kinase increases from embryonic day 4–15. It decreases with further development. In the same membrane preparations active Ca 2+ ‐uptake into vesicles of sarcoplasmic reticulum rises from day 4–7 and decreases then slightly until day 20. A several‐fold increase in Ca 2+ ‐transport activity occurs at the time of hatching. The data indicate separate genetic control for synthesis of phospholamban and sarcoplasmic reticulum Ca 2+ ‐ATPase.