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Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide
Author(s) -
Kiso Yoshiaki,
Kitagawa Kouki,
Nobuyuki Kawai,
Akita Tadashi,
Takagi Hiroshi,
Amano Hiroo,
Fukui Kiyoshi
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80621-2
Subject(s) - analgesic , peptide , chemistry , pharmacology , medicine , biochemistry
The amino acid sequence of a newly isolated pentapeptide, neo‐kyotorphin from bovine brain was synthetically verified to be Thr‐Ser‐Lys‐Tyr‐Arg corresponding to the C‐terminal portion of hemoglobin α‐chain. The synthetic neo‐kyotorphin showed the dose‐dependent analgesia in mice which was approximately equal to that of Leu‐enkephalin.