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Inhibition of DNA replication in vitro by pefloxacin
Author(s) -
Badet Bernard,
Hughes Patrick,
Kohiyama Masamichi,
Forterre Patrick
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80199-3
Subject(s) - pefloxacin , oxolinic acid , replication (statistics) , dna replication , plasmid , in vitro , chemistry , dna , antibiotics , nalidixic acid , biology , microbiology and biotechnology , ofloxacin , escherichia coli , biochemistry , gene , virology , ciprofloxacin
Pefloxacin (a novel quinolone antibiotic) is demonstrated to be a drug inhibiting DNA replication 10‐times more efficiently than oxolinic acid measured either in toluene‐treated E. coli or in an in vitro replication system for oriC plasmids [6]. DNA repair synthesis is not inhibited by the drug.