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Influence of estrogen, progesterone and estrous cycle on γ‐glutamyltranspeptidase of rat endometrium
Author(s) -
Tarachand U.,
Eapen Jacob
Publication year - 1982
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(82)80049-5
Subject(s) - estrous cycle , estrogen , research centre , citation , library science , endometrium , andrology , gynecology , biology , endocrinology , medicine , computer science
The endometrium of rat uterus undergoes a variety of histophysiological changes during estrous cycle, pregnancy and lactation. These alterations, governed by the actions of endogenous steroids, exhibit characteristic biochemical features. Of the metabolic changes, altered syntheses of enzymes are more pronounced in the endometrium [l-4]. Camma-glutamyltranspeptidase (GGT; EC 2.3.2.2), a membrane-bound enzyme catalysing the transfer of y-glutamyl moiety of glutathione to amino acid, is detectable in a variety of mammalian tissues [ 51. Biochemical and histological changes related to implantation are more pronounced in the endometrium and our earlier investigation noted the rise of GGT activity in the endometrium during deciduoma progression and higher activity in the implantation areas of uteri from gravid rats [4]. Since endogenous hormones related to pregnancy have a major influence on the heterogeneous population of endometrial cells, it was interesting to study the influence of exogenous estrogen and progesterone on endometrial GGT of ovariectomized rats. We report here that administration of estrogen or progesterone to rats 15 days after ovariectomy enhances GGT activity in the endometrium. Response to estrogen is noticeable earlier than that to progesterone. In addition, data on endometrial enzyme activity of normal cycling rats are also presented.