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Interaction between latent papovavirus genomes and the tumor promoter TPA
Author(s) -
Krieg Peter,
Amtmann Eberhard,
Sauer Gerhard
Publication year - 1981
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(81)80078-6
Subject(s) - german , papovavirus , library science , citation , research center , virus , classics , biology , virology , philosophy , history , political science , computer science , law , linguistics
The tumor promoting agent 12-O-tetradecanoylphorbol-13acetate (TPA) enhances both the transformation of rat embryo cells by adenovirus and the cloning efficiency of such cells [ 11. Induction of Epstein-Barr virus (EBV) antigens and stimulation of particle synthesis by treatment of the EBV-carrying cell lines with TPA was reported in [ 2,3]. Here we report that TPA exclusively enhances the viral DNA content of cells which harbor papovavirus genomes in a latent episomal state. On the other hand, no effect is exerted by TPA on the copy number of the viral DNA in productively infected cells and on integrated papovavirus DNA in transformed cells.