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Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanol
Author(s) -
Rommelspacher Hans,
Strauss Sabine,
Lindemann Jürgen
Publication year - 1980
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(80)81088-x
Subject(s) - chemistry , philosophy
It is well known that ethanol is oxidized to acetaldehyde in the mammalian organism. Whether the symptoms of acute or chronic ethanol ingestion are caused exclusively by ethanol and acetaldehyde remains to be elucidated. Further pharmacodynamitally active substances may be formed in the organism by other metabolic reactions, such as tetrahydroharmane (THH), also known as eleagnin, which is the condensation product of acetaldehyde and tryptamine. In principle the reaction occurs in vivo, since it was demonstrated in man and rat for tryptamine and 5hydroxytryptamine with formaldehyde yielding tetrahydronorharmane and 6-hydroxytetrahydronorharmane, respectively. Here, the existence of the /3-carbolines THH and harmane in the urine of man and rat is demonstrated.