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Inhibition of catalase in vitro and in vivo by 4‐hydroxypyrazole, a metabolite of pyrazole
Author(s) -
MacDonald Ewen,
Pispa Jaakko P.
Publication year - 1980
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(80)81046-5
Subject(s) - in vivo , metabolite , in vitro , chemistry , pharmacology , library science , computer science , biochemistry , medicine , biology , microbiology and biotechnology
For many years it has been recognised that not all the properties of pyrazole are due to the molecule itself [l-4]. With the elucidation of the metabolism of pyrazole [S] it was appreciated that several metabolites could possess biological activity. In {6] an in vitro inhibition of catalase (EC 1 .l 1 .1.6) by 4-hydroxypyrazole (4-HP), one of the major metabolites of pyrazole was reported. This paper confirms the inhibition of catalase by 4-HP but also describes the importance of incubation time, a factor not studied earlier. We also describe the effects of 4-HP administration to mice on liver catalase activity.