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Regulation of ovarian gonadotropin receptors and LH bioactivity during the estrous cycle
Author(s) -
Solano A.R.,
Vela A.Garcia,
Catt K.J.,
Dufau M.L.
Publication year - 1980
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(80)80433-9
Subject(s) - vela , reproductive health , reproductive endocrinology , gynecology , medicine , endocrinology , hormone , population , physics , pulsar , astrophysics , environmental health
Regulation of LH receptors in the testis [ 1,2] and ovary [3] by elevation of circulating gonadotropins is a well-recognized phenomenon, but the relation of such changes to the physiological control of gonadal function has not been established. Also, the biological potency of circulating LH has been found to change during the primate estrous cycle [4], suggesting that a more potent form of the hormone is released at midcycle. To analyze the contributions of receptor regulation and LH bioactivity to the cyclical control of ovarian function, we measured gonadotropin receptors and bio:immuno (B:I) ratios of pituitary and serum LH throughout the rat estrous cycle. These studies showed that the preovulatory surge of LH is released from a pituitary pool of high biological activity. Also, negative regulation of gonadotropin receptors and positive regulation of prolactin were clearly identified as physiological components of the ovarian cycle.