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Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility
Author(s) -
Foidart J.,
Sraer J.,
Delarue F.,
Mahieu P.,
Ardaillou R.
Publication year - 1980
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(80)80375-9
Subject(s) - mortise and tenon , mesangial cell , chine , humanities , art , china , political science , medicine , geography , kidney , archaeology , law
Specific receptors for angiotensin II (A II) have been shown in glomeruli isolated from rat kidney cortex and related to glomerular vase-reactivity [l]. The localization of A II receptors within the glomerulus and the relationship between these receptors and the physiological functions of the corresponding cells are still unknown. After injection of tritiated A II into the renal artery of the rat, 3H radioactivity was observed by autoradiography in the mesangial cells [2], but the physiological significance of this uptake remained imprecise. High affinity binding sites for A II on rat glomerular basement membranes were observed [3] but no experimental data allowing correlation of this binding with a physiological function was provided. Homogeneous populations of glomerular epithelial and mesangial cells have now been cultured [4,5]. It is thus possible to study the biochemical properties of these two different glomerular cell populations. We have shown that the mesangial cells represent the main site of prostaglandin (PC) E2 glomerular synthesis [6]_ Here, we provide evidence for localization of specific A II receptors on the mesangial cells and demonstrate that the binding of A II to these receptors induces a contractile response of mesangial cells.