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Preuroporphyrinogen, a universal intermediate in the biosynthesis of uroporphyrinogen III
Author(s) -
Jordan P.M.,
Berry A.
Publication year - 1980
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(80)80134-7
Subject(s) - citation , berry , library science , chemistry , computer science , biology , botany
Since their initial recognition over 20 years ago [l-3] the two enzymes which catalyse the formation of uroporphyrinogen III (I ), namely porphobilinogen deaminase and uroporphyrinogen III cosynthetasef , have been isolated from a variety of sources (reviewed [4]). Numerous attempts have been made to unravel the mechanism by which the enzymes catalyse the formation of uroporphyr~nogen III, the key intermediate in the biosynthesis of heme, chlorophylls and corrins. Until recently, the two enzymes had been widely considered to function in a complex with the catalytic events between porphobiI~nogen and uroporphyrinogen III occuring through enzyme bound intermediates. This has been arrived at by surmise rather than from direct experimental observations (reviewed I-m Our concept of the mechanism by which the tetrapyrrole ring is biosynthesised has been totally altered by reports that in the photosynthetic bacterium