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Formation of relatively persistent O 2 ‐ethylthymidine by diethylnitrosamine in rat liver DNA
Author(s) -
Steward A.P.,
Scherer E.,
Emmelot P.
Publication year - 1979
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(79)81161-8
Subject(s) - carcinogenesis , cancer , medicine
O-Alkylation of DNA by chemical carcinogens or mutagens has been considered as a relevant event in carcinogenesis and mutagenesis [l] . Besides O6 of guanine and the phosphate groups, the 0 of pyrimidines are sites of modification [2-61. 04-Alkylthymidine was detected after in vitro and in vivo alkylation of DNA [7-91 and 02-alkylthymidine after reaction of DNA in vitro or in cultured cells [9,10] . We now report the identification of 02ethylthymidine in liver DNA of rats given the hepatocarcinogen DEN. Despite the apparent lack of miscoding in vitro [l] , the relative persistence of this lesion in vivo may indicate a relevant role in hepatocarcinogenesis.