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1,25‐Dihydroxycholecalciferol: Dynamics of the stimulation of duodenal calcium‐binding protein, calcium transport and bone calcium mobilization in vitamin d and calcium‐deficient rats
Author(s) -
Thomasset Monique,
Cuisinier-Gleizes Paulette,
Mathieu Henri
Publication year - 1979
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(79)80470-6
Subject(s) - calcium , humanities , medicine , art
1 ,25(OIQ2D, is presently known as the most potent and rapidly acting metabolite of vitamin Da in increasing intestinal calcium absorption and bone calcium mobilization [ 11. Intestinal CaBP synthesis can be considered to be a molecular expression of the hormonal action of 1,25(OH)aDa on the enterocyte [2] and consequently a sensitive index of the intestinal response to various metabolites of vitamin Da ]3,41. With the aim of assessing the relation of the vitamin D-dependent CaBP to calcium absorption, the time course of intestinal changes in calcium absorption and CaBP levels in response to 1 ,25(OH)zD3 has received considerable attention in the chick [S-7] but has not yet been investigated in mammals. Using a highly sensitive and specific RIA, recently developed in the rat 181, we report here, in this species, the dynamic of changes in intestinal CaBP levels in response to 1 ,25(OH)zDa. The changes in calcium transport and bone calcium mobilization were also examined.