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Actions of adenosine and guanosine 3′ : 5′ cyclic phosphorothioates on histamine secretion
Author(s) -
Eckstein F.,
Foreman J.C.
Publication year - 1978
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(78)81167-3
Subject(s) - boulevard , guanosine , reprint , chemistry , library science , medicine , computer science , biochemistry , history , physics , archaeology , astronomy
Free peritoneal mast cells of the rat are used as a model for the study of secretion. Adenosine 3’: 5’ cyclic monophosphate itself has no effect on the secretion of histamine from mast cells, presumably because it cannot pass across the membrane into the cell. UsingN602’-dibutyryl 3’: 5’ cyclic adenosine monophosphate which can penetrate into cells, and other agents which cause a rise in the intracellular level of 3’: 5’ cyclic adenosine monophosphate (cyclic AMP), it has been shown that intracellular cyclic AMP is able to exert an inhibitory effect on the secretion of histamine-containing granules from mast cells [l--4]. The inhibitory action of cyclic AMP appears to be the result of inhibition of the influx of calcium into mast cells [5,6], which is the initial and essential step in the secretory process of these cells [7]. In contrast to the action of cyclic AMP, it has been reported that 8-bromo cyclic guanosine monophosphate enhances the secretory response of mast cells in human lung [8].