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Lanthanide‐sensitive calcium—monocarboxylate symport in rat liver mitochondria
Author(s) -
Moyle Jennifer,
Mitchell Peter
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)81073-9
Subject(s) - chemistry , citation , library science , art history , art , computer science
Our recent observations [ 1,2] on lanthanidesensitive calcium and strontium translocation in rat liver mitochondria show that the electric charge stoicheiometry of calcium translocation should be represented not as "--Ca 2÷, but as ~--Ca ÷, and that bivalent cation translocation may be catalysed by a (Ca2)4~-HPO~ symporter. These observations suggest that the import of calcium and monocarboxylates by respiring mitochondria [3], and the swelling of nonrespiring mitochondria in isotonic calcium or strontium acetate solutions in the presence of protonconducting uncouplers [4], may involve bivalent cation-monocarboxylate symport, either mediated by the (Ca2)a+-HPO~ symporter or by a Ca2+-mono carboxylatesymporter. In this paper we provide evidence for specific bivalent cation-monocarboxylate symport. Mitochondria respiring in State 6, in the presence of excess calcium or strontium salt, show a lanthanide-sensitive monocarboxylate-dependent respiratory stimulation and import of bivalent cation, when the recirculation