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Complex glycosphingolipids with blood‐group a specificity
Author(s) -
Slomiany Bronislaw L.,
Slomiany Amalia
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)80975-7
Subject(s) - citation , medicine , library science , computer science
The oligosaccharide chains present in blood-group ABH glycoproteins and glycolipids of glandular epithelial tissue exhibit a considerable degree of heterogeneity with respect to length of carbohydrate chains and degree of branching [l-6] . The sizes of the largest blood-group-active oligosaccharide chains from horse gastric mucosa are in the range of 812 sugar residues [7] , whereas those from hog gastric mucosa [I ,3,8] and human cyst fluid [2,4] are closer to 16-l 8 residues or even larger [2] . Glycolipids of unusual complexity with 30-50 sugar residues have recently been isolated from human erythrocyte membrane by Gardas and Koscielak [9,10]. So far the existence of glycolipids of comparable carbohydrate structures in glandular epithelial tissue have not been reported. In this report we describe the isolation and characterization of two blood-group A-active glycolipids, the carbohydrate portions of which consist of 12 and 18 sugar residues.