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Altered levels of cyclic nucleotides, cyclic AMP phosphodiesterase and adenylyl cyclase activities in normal, dysplastic and neoplastic human mammary tissue
Author(s) -
Küng W.,
Bechtel E.,
Geyer E.,
Salokangas A.,
Preisz J.,
Huber P.,
Torhorst J.,
Jungmann R.A.,
Talmadge K.,
Eppenberger U.
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)80895-8
Subject(s) - medicine , gynecology
Recently, we have reported decreased cellular levels of CAMP-dependent protein kinase and CAMP-binding activity in neoplastic human mammary tissue [l] . Considering the sensitivity of the CAMP-protein kinase system to changes of CAMP, it was important to determine intracellular levels of this cyclic nucleotide and to identify changes of phosphodiesterase and adenylyl cyclase activities, the two enzyme systems which directly regulate the intracellular CAMP metabolism. Recently, increased levels of CAMP were reported in human mammary carcinomas [2] . Our results show that neoplastic mammary tissues exhibit increased specific levels but decreased cellulsr levels of CAMP and cGMP. In addition, the cellular activities of adenylyl cyclase phosphodiesterase are significantly lower in neoplastic as compared with normal human breast tissues.