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Effect of glucose on K + handling by pancreatic islets
Author(s) -
Boschero A.Carlos,
Kawazu Shoji,
Duncan George,
Malaisse Willy J.
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)80662-5
Subject(s) - biological sciences , library science , medicine , biology , computer science , computational biology
Data are presented which confirm and extend conclusions derived from previous experiments carried out with 86Rb+. They suggest that glucose, by reducing the permeability of the plasma membrane to effluent K+, increases the concentration of K+ in the islet cells and under steady-state conditions, reduces proportionally the fractional turnover rate of the cellular K+ pool. Glucose, however, does not increase the inflow-outflow rate of K+ into the islet cells. The mechanism by which glucose affects the permeability of the plasma membrane to effluent K+ remains to be elucidated.SCOPUS: ar.jinfo:eu-repo/semantics/publishe