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Thyroid hormone control of cyclic nucleotide phosphodiesterases and the regulation of the sensitivity of the liver to hormones
Author(s) -
Gumaa K.A.,
Hothersall J.S.,
Greenbaum A.L.,
McLean Patricia
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)80403-1
Subject(s) - thyroid hormones , biochemistry , medicine , hormone
One of the more striking, but least studied, aspects of thyroid action is its effect on the hormone responsiveness of tissues. The action of lipolytic hormones such as glucagon, catecholamines and ACTH is markedly reduced in adipose tissue following thyroidectomy, while the action of insulin is potentiated after administration of thyroid hormone [l] . Insulin and glucagon both modulate the cyclic nucleotide content of liver and adipose tissue, insulin causing a rapid and transient rise in cGMP [2,3] and glucagon a marked rise of CAMP [4,5] . The reports that there is an increase of CAMPand cGMP-phosphodiesterases in adipose tissue following thyroidectomy [6-91 may well be particularly relevant to these tissue responses to hormones. The similarities in the response to thyroidectomy of the enzymes of carbohydrate metabolism and of fatty acid synthesis in rat liver and adipose tissue [lo] prompted the present study of the enzymes regulating the tissue level of the cyclic nucleotides in rat liver. Changes in the balance of the enzymes adjusting the tissue content of these nucleotides could provide a common locus for thyroid action in a number of tissues responsive to insulin and glucagon and thus act as a unifying factor in the coordination of liver and adipose tissue metabolism.