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Glucagon stimulation of mitochondrial ATPase and potassium ion transport
Author(s) -
Yamazaki Russell K.,
Sax Robert D.,
Hauser Michael A.
Publication year - 1977
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(77)80106-3
Subject(s) - library science , chemistry , computer science
The hormone glucagon stimulates hepatic gluconeogenesis. Studies on the mechanism of this stimulation have centered upon those changes manifested in the hepatic mitochondria after the hormonal treatment [l-5] . Recently, acute glucagon treatment of fed, intact rats has been shown to produce a stimulation of respiration with a number of substrates in isolated, hepatic mitochondria [5]. Rates of respirationdependent ADP phosphoiylation, Ca2+-uptake, and uncoupled oxygen-uptake are stimulated after the hormonal treatment. Rates of pyruvate metabolism [l-3] and citrulline formation [4] are also stimulated under the same conditions. In an attempt to determine which components of the mitochondria have been altered by the hormonal treatment, a survey of a number of mitochondrial properties is being carried out. In this report, the effect of acute glucagon treatment upon rates of uncoupler-induced ATPase activity and K’-accumulation in intact mitochondria has been determined. Glucagon treatment has been found to cause a stimulation of both processes.