Premium
Comparison between a biological and a radioimmunological assay of plasma renin concentration
Author(s) -
Lijnen Paul J.,
Amery Antoon K.P.C.,
Fagard Robert H.
Publication year - 1976
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(76)80164-0
Subject(s) - plasma renin activity , renin–angiotensin system , medicine , radioimmunoassay , endocrinology , chemistry , blood pressure
Variability in incubation conditions for generating angiotensin has made comparison between bioassay and radioimmunoassay of plasma renin activity difficult to interpret. Haas and Goldblatt [ 1] found that the plasma renin concentration of normal volunteers determined by radioimmunoassay was lower than the bioassay values. Hollemans et al. [2] reported that, with use of the same plasma extracts for assay, the angiotensin concentration was consistently lower by radioimmunoassay than by bioassay. Others have found that values for plasma renin activity obtained by radioimmunoassay are higher than by bioassay [3-51 or comparable to bioassay values [6,7]. We have measured the plasma renin concentration of the same pre-extracted human plasma samples by both a bioassay and a radioimmunoassay technique.