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Elaboration of medium chain free fatty acids and long chain fatty acid prostaglandin precursors by isolated anoxic rat liver mitochondria
Author(s) -
Markelonis George,
Garbus Joel
Publication year - 1975
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(75)80842-8
Subject(s) - reprint , citation , george (robot) , medicine , library science , history , art history , physics , computer science , astronomy
Mitochondria isolated from ischaemic tissues or ‘aged’ in vitro exhibit a diminished capacity for oxidative phosphorylation [l-4] . Among the factors implicated has been the liberation of free fatty acids (FFAs) which have been demonstrated to be potent uncoilplers of oxidative phosphorylation [5] . A similar deterioration of function was observed during a study of the effects of anoxia upon isolated mitochondria. Determination of liberated FFAs in such experiments revealed an increase not only in medium chain FFAs, but also in polyunsaturated long chain FFAs which are known precursors of the prostaglandins. Since the effects of anoxia have been implicated in cell injury, the elaboration of such prostaglandin precursors may have a role in the cell’s response to anoxic injury.