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Energy transduction and proton translocation by adenosine triphosphatases
Author(s) -
Boyer Paul D.
Publication year - 1975
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(75)80464-9
Subject(s) - citation , library science , chemistry , computer science
In a recent letter to this journal, Peter Mitchell [ 1 ] suggested a mechanism for ATP synthesis coupled to a proton gradient across a membrane. This essentially represents an amplification of the component of his chemiosmotic hypothesis concerning how a potential gradient is used, the other components of the hypothesis being how oxidative energy may generate a proton or potential gradient and the function of such gradients to transmit energy from oxidation to phosphorylation sites. depicted as undergoing successive addition of two protons, the second addition being accompanied by reaction with ADP to give a pentacovalent species containing an oxonium ion (-OH;) group.:This species is depicted as losing water to form ATP. The scheme thus accounts for use of two protons per ATP molecule synthesized, in accord with Mitchell’s earlier proposals. Besides suggesting different intermediates for coupled hydrolysis and synthesis, the scheme has other deficiencies, among which are the following: