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Structural transformations of ribosomes (dissociation, unfolding and disassembly)
Author(s) -
Spirin A.S.
Publication year - 1974
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(74)80687-3
Subject(s) - citation , ribosome , dissociation (chemistry) , computer science , library science , chinese academy of sciences , chemistry , political science , rna , biochemistry , law , china , gene
Besides morphological descriptions the following is known about ribosomes: (1) each complete ribosome is always constructed from two loosely associated unequal subparticles (subunits); (2) each subparticle consists of one molecule of high-polymer RNA (plus low molecular-weight RNA for the large subparticle) and numerous molecules of ribosomal protein; (3) all, or almost all the ribosomal proteins in the ribosomal subparticle are different; (4) the molecule of highpolymer ribosomal RNA ensures the assembly of these different proteins into a ribonucleoprotein particle, and, in one way or another, unites them on the basis of its covalent structure; (5) as a whole the particle (subparticle) is characterized by a unique, asymmetric and at the same time rather compact packing of its components. The discovery of structural transformations of the ribosomal particles in vitro such as dissociation, unfolding and disassembly, has played an important role in the formation of contemporary knowledge and concepts on ribosomes.