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Interaction of human serum high density lipoproteins with triglycerides in vitro
Author(s) -
Koren E.,
Marić Z.,
Milković S.
Publication year - 1974
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(74)80302-9
Subject(s) - citation , library science , humanities , philosophy , computer science
Almost twenty years ago Kom [l] put forward a hypothesis that between chylomicrons and cw-lipoproteins there exists a recycling system which is responsible for the transport of a part of triglycerides in the human body. So far this hypothesis has neither been refuted nor supported by direct experimental evidence. There is, however, some indirect evidence in favor of Kom’s concept: it has been established, for example, that following injection of heparin very low density lipoproteins (VLDL) in human plasma decrease and high density lipoproteins (HDL) increase [2]. Experiments in which the distribution of labelled VLDL and HDL apoproteins was studied following intravenous administration showed that transformation of VLDL into lipoproteins of higher density exists both in man and rat [3-61. However, only some vague hints at the possibility of re-utilization of VLDL apoproteins have been given [6] . In this communication experimental evidence is presented on the formation of VLDL from human HDL and triglycerides in vitro.